Analgin with Diphenhydramine – dosage for injection to a child

In cases where a child’s fever refuses to subside despite standard medication, physicians may prescribe an injection of a combination of Analgin and Diphenhydramine. In an emergency, this mixture is frequently used to quickly lower fever and minimize discomfort.

It’s critical to comprehend the proper dosage and the interactions between these drugs. A child who is ill can benefit from the particular effects of both the antihistamine Diphenhydramine and the painkiller Analgin.

However, due to the possibility of unintended side effects, caution must be exercised when using these medications. Before using this combination on their child, parents should always speak with a healthcare provider to make sure it’s suitable and safe for their child’s circumstances.

Features of drugs

One non-steroidal medication in the anti-inflammatory class is analgin. Its solution comes in ampoules that hold one milliliter and two milliliters. In this solution, the concentration of the active ingredient, metamizole sodium, is either 25% or 50%. There are five or ten ampoules per package. All that’s in them is the active ingredient and sterile water.

Analgin can be injected intravenously or directly into muscle, although the latter is only done in a medical facility. Giving an intravenous injection of such a drug at home is unacceptable. Analgin comes in tablet and suppositories with varying dosages in addition to the injection form.

Diphenhydramine is a representation of the active ingredient in the injection solution. This medication acts on histamine-sensitive H1 receptors. It is an antihistamine. The concentration of the active ingredient in ampoules is 10 mg, and each one has one milliliter of solution in it. They are offered for sale in cardboard ten-piece packs. Additionally, diphenhydramine comes in tablet form, with each tablet containing 50 mg of the drug.

The medication is designed to be injected intramuscularly and intravenously. Such injections are only prescribed in hospitals because, in this instance, the introduction into the vein, like with Analgin, should be strictly supervised by medical professionals. The medication may only be injected into the muscles at home.

Why they are prescribed together?

When combined, analgesic and diphenhydramine improve each other’s therapeutic effects. This mixture is called lytic because these drugs, when taken simultaneously, help with high temperatures very quickly. In this combination, analgin has both analgesic and antipyretic properties.

Diphenhydramine’s function is to reduce edema and relax smooth muscles. This medication also prevents an allergic reaction to the administration of a combination of drugs and has a sedative effect.

The injection’s effects become apparent ten to fifteen minutes after the drugs are injected intramuscularly. For most patients, the injection’s effects last for up to four hours. The risk of high temperatures for children is the primary indication for the use of this combination of medications. A high rate of injection (above 39 degrees) and a higher risk of seizures are common.

From what age can it be used?

Analgin may be used in children older than three months, per the instructions; however, at younger ages, this drug must be administered strictly in accordance with prescription guidelines and under the guidance of a physician. Giving an injection on your own to a child younger than two or three years old is risky. A child under one year old should only receive an injection intramuscularly if one is prescribed.

Pediatrics allows the use of a diphenhydramine solution starting at age one. Since the antihistamine medication’s solution can be given intramuscularly to infants older than one month, Suprastin is used in place of the original medication if injections are required for children aged three to twelve months.

When an injection cannot be given?

A lytic mixture injection shouldn’t be done:

  • if there is intolerance to any component;
  • if there are problems with hematopoiesis;
  • if there are serious liver diseases;
  • if there is renal failure;
  • if there is bronchospasm;
  • if there is diabetes.

Additionally, if the cause of the acute abdominal pain has not been determined, it is not permitted to administer an injection (removing the pain may impede the accurate diagnosis and exacerbate the child’s condition).

If a small patient has bronchial asthma, allergies, hypotension, or an injury, administering injections should be done carefully and under medical supervision. Should the infant’s health be in any way jeopardized, you ought to decline Analgin and opt for a more secure antipyretic medication for kids, like Paracetamol.

To guarantee safety and efficacy when giving Analgin with Diphenhydramine to a child, it’s critical to know the proper dosage. Depending on the child’s weight and age, the dosage for this combination must be carefully calculated in order to reduce fever or relieve pain. It is imperative to speak with a healthcare professional before giving these drugs because the wrong dosage can have detrimental effects or complications. Ignore medical advice at all times and always heed it.

Side effects

Analgin and diphenhydramine injected together can:

  • greatly lower body temperature for a long period;
  • provoke an allergic reaction;
  • lower blood pressure;
  • cause fainting;
  • disrupt the digestive tract;
  • impair the production of leukocytes, which in some cases leads to agranulocytosis.

Abdominal pain, drowsiness, convulsions, bleeding, shortness of breath, and other dangerous symptoms are caused by taking too much medication. A child who overdoses on analgin and diphenhydramine frequently needs to be hospitalized in order to support critical hospital functions.

Dosage

It is advisable to determine the child’s Analgin dosage based on his weight if he is younger than eight years old. Multiplying the child’s weight in kilograms by five or ten yields the daily dosage of such a medication. A calculation like this precisely establishes how many milligrams of metamizole sodium are acceptable for a given child.

Two to three single doses of the resultant amount are given. In this instance, they shouldn’t go over 100 mg for kids under three and 200 mg for kids between three and eight years old. Analgin’s active ingredient is 250–300 mg in a single dosage for children over 8, and 500 mg in doses for those over 14.

The child’s age determines the dosage of the diphenhydramine injection solution:

  • If the baby is from 1 to 3 years old, then 0.5 ml of the drug is administered, but the dose can be increased to 1 ml of the drug if necessary.
  • For children 4-6 years old, the dose of the solution for one injection is from 1 to 1.5 ml.
  • At the age of 7 to 14 years, 1.5-3 ml of the drug is taken for one injection.

How to give an injection?

You will need a long needle and sterile syringe for this manipulation. It is necessary to clean the ampoule and the skin surrounding the injection site, perhaps by lubricating them with medical alcohol. Ampoules containing medications should be held in your hand for a while before opening to allow the solution to slightly warm.

Since the instructions advise against combining Analgin with other drugs, you should prepare the injection by drawing up the medication and injecting it into the muscle first. Then, using the same syringe, draw up Diphenhydramine and inject it through the same needle, leaving it in the body. In actuality, though, they frequently use simultaneous administration. The ampoules are opened, and one syringe is filled with each medication in turn. Analgin should typically be diluted with diphenhydramine before being poured.

To ensure that the medications reach the muscle tissue, it is best to inject them into the shoulder or thigh muscle. An inflammatory response or irritation will result from injecting the medication under or into the skin. Because the gluteal muscles are situated quite deep, an injection into the gluteal region is therefore less ideal.

On the "Live Healthy" program, Elena Malysheva and her colleagues will explain and demonstrate in detail how to administer an injection into the buttocks correctly.

Use for "white" hyperthermia

This is the term for a condition where the baby’s skin turns pale, their limbs and forehead feel cool to the touch, and their temperature rises on the thermometer. Peripheral vascular spasm is the cause of these symptoms, which impair heat transfer.

Treatment strategies for "red" hyperthermia and this fever vary. It is crucial to give the child warm liquids and to massage and rub his skin. Antispasmodic medications must be added to the "Analgin + Diphenhydramine" combination for the treatment of "white" fever.

Such a mixture is known as "troychatka" because three drugs are given at once. Drotaberone is the active ingredient in No-shpa, the third most popular medication. This drug contributes to the expansion of vascular spasms and helps to eliminate them. Children older than one year old are prescribed it.

Papaverine, a medication with a comparable therapeutic effect, frequently takes the place of no-shpa. It is administered to children older than six months in a 2% solution. This medication dilates blood vessels and effectively stops spasms. In extreme circumstances, the physician might also give the child prescriptions for Dexamethasone or other drugs.

Age of Child Recommended Dosage of Analgin and Diphenhydramine
1-3 years 50-100 mg Analgin + 0.2-0.3 ml Diphenhydramine
4-7 years 100-200 mg Analgin + 0.3-0.5 ml Diphenhydramine
8-12 years 250-500 mg Analgin + 0.5-1.0 ml Diphenhydramine
13-18 years 500-750 mg Analgin + 1.0-1.5 ml Diphenhydramine

It’s important to use caution when giving Analgin and Diphenhydramine to children. These drugs can efficiently control pain and lower fever, but they have to be taken under a doctor’s supervision. To guarantee safety and prevent any negative effects, the dosage must be used correctly.

Before giving these medications, especially if they require injections, always get medical advice. Following recommended dosages and guidelines is crucial because self-dosing without medical advice can cause issues.

It is equally important to closely monitor your child following the injection. Seek medical attention right away if any unusual symptoms, such as an allergic reaction or protracted tiredness, appear. The security of your child should always come first.

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Svetlana Kozlova

Family consultant and family relationship specialist. I help parents build trusting relationships with their children and each other. I believe that a healthy atmosphere in the home is the key to happiness and harmony, which I share in articles and recommendations.

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