“Clexane” during pregnancy: instructions for use

During pregnancy, many women may encounter the drug "clexane," particularly if blood clotting is a concern. This medication is frequently prescribed to help avoid blood clot complications, which can be extremely dangerous for both the mother and the unborn child.

The physical demands of pregnancy can sometimes cause a woman’s blood to become more prone to clotting. To lower this risk and guarantee a healthier pregnancy, doctors might advise taking "Clexane." When women are more likely to develop deep vein thrombosis or other clotting disorders, it is frequently used.

This article will discuss the use of "Clexane" during pregnancy, how to follow the directions, and what to do if your doctor prescribes it. It’s critical to comprehend how this medication functions and how it can safeguard the mother and child.

Features of the drug

One medication from the class of direct-acting anticoagulants is called "Clexane." Like many other drugs in this class, it is only produced in injectable form by the company "Sanofi." The medication is a transparent, light yellow or colorless liquid. It comes in glass syringes that are individually packaged and hold between 0.2 and 0.8 ml of solution. There are two or ten syringes in each pack.

"Enoxaparin sodium" is the compound that gives "Clexane" its action. The dose is expressed in anti-Xa IU, a unique unit of measurement. There are 1000 of these units per 0.1 ml, meaning that each syringe holds between 2000 and 8000 anti-Xa IU. Sterile water serves as the sole excipient. The medication has a three-year shelf life, must be purchased with a prescription, and should be stored at a temperature below +25 degrees.

Principle of action

The primary component of "Clexane" is low molecular weight heparin, which is produced by alkaline hydrolysis of heparin. Because of its strong anti-Xa activity, the medication inhibits blood coagulation factor X, which becomes the Xa form when activated. One purpose of such a factor is to promote prothrombin’s conversion to active form IIa, which leads to the formation of thrombin and blood clots. As a result, using "Clexane" stops prothrombin from activating, preventing blood clots from occurring in areas where they are highly likely to occur.

Is it allowed during pregnancy?

The instructions for "Clexane" indicate that there is no information about the possibility of penetration of the active substance of the drug through the placental barrier, since studies of this drug with the participation of pregnant women have not been conducted. Despite the fact that in animals such a medication did not cause any negative consequences, it is difficult to vouch for their absence, therefore the use of "Clexane" during pregnancy is allowed only in exceptional situations, when it is impossible to do without it. Usually the drug is prescribed based on laboratory test data, if they confirm a high risk of thrombosis. In such cases, the occurrence of blood clots threatens the life of both the expectant mother and the fetus, so the use of "Clexane" will be justified.

In order to avoid bleeding and a drop in platelet count, the pregnant patient should continuously monitor her condition and have tests performed during treatment.

In the 1st trimester, they still try to refuse the use of "Clexane", if such an opportunity exists. At this time, the fetus"s organs are just beginning to form, and the risk of an adverse effect on this process is quite high. Injections in the early stages are in demand after IVF, as well as for patients with miscarriage, the cause of which are problems with blood coagulation. For such women after a frozen pregnancy or miscarriage, Clexane is injected even during conception planning. In the later stages, the enlarged uterus presses on the vessels, which contributes to blood stagnation and the formation of clots. It is especially dangerous if blood clots appear in the placental blood flow system, because this prevents oxygen from reaching the baby and can provoke serious complications. For this reason, the doctor may prescribe Clexane at 33 weeks or another period, but with increased caution.

A drug called "clexane" is frequently administered to expectant mothers in order to prevent blood clots, particularly for those with certain medical disorders that raise their risk. The dosage and timing of medication should be carefully followed by the patient, as they may change depending on their specific medical needs. Even though it’s generally safe when used properly, it’s important to regularly check in with your healthcare provider and keep an eye out for any side effects to ensure the safety of both mother and child.

When it is prescribed to expectant mothers?

• with a high risk of venous thrombosis due to general surgical or orthopedic manipulations;
• if a woman had to maintain bed rest for a long time, which can also be an aggravating factor for the appearance of blood clots;
• if blood clots are detected in deep veins, as well as with thromboembolism;
• if the patient is on hemodialysis;
• If you diagnosed unstable angina pectoris or acute myocardial damage.

Contraindications

The physician may decline to administer Clexane to a patient who has been found to be hypersensitive to enoxaparin or other direct anticoagulants, even if the patient is a woman. In cases where there is a risk of developing a side effect, such as vascular aneurysms, pericarditis, vasculitis, diabetes, high blood pressure, or recent eye or brain surgery, the drug is contraindicated in the presence of bleeding and should be used cautiously.

If the woman has previously taken this medication and it resulted in significant side effects, like a drop in platelets, then clexane is not recommended. To prevent overdosing when a person has a low body weight, care and accurate dosage calculation are required.

Should the drug be recommended during the third trimester and epidural anesthesia is intended, the anticoagulant should be stopped at least 12 hours prior to the procedure.

It is imperative to discuss the drug compatibility of "Klexana" separately, as there are numerous limitations on its use due to potential drug interactions. Therefore, injections should not be combined with systemic glucocorticoids (with Metizkhotmor) or other thrombolytics (with "fragmine," "heparin," or "thromboass"). The attending physician needs to clarify whether using Tramsam, Dycinon, Angiovite, Duphaston, and other medications together is possible.

Side effects

The majority of women who used Klexans while pregnant report experiencing local side effects. These include swelling, bruises, pain, injection site redness, skin inflammation, the formation of seals, and more. You should notify the attending physician about such phenomena if they cause the future mother any discomfort.

Bleeding is a less frequent adverse "Clexane" reaction. If a woman concurrently takes other blood-related medications, for instance, her occurrence may be increased by additional risk factors. Hemostases, nosebleeds, blood in the urine, vaginal spotting (brown discharge), petechiae, and other side effects are examples of this type of reaction.

A medication dosage that is too high may also cause them.

Women taking "Clexane" may have higher platelet counts in general blood tests, but thrombocytopenia is occasionally also seen. An additional adverse consequence of a biochemical blood test is elevated liver enzyme activity. Furthermore, a few patients experience allergic reactions to the medication, such as urticaria, skin itching, or other allergy-related symptoms.

Instructions for use

The majority of the time, Clexane is applied subcutaneously; intramuscular administration of the medication is not permitted. A venous catheter is used to inject the medication intravenously if life is in danger. In this instance, the medication may only be mixed with 5% glucose or saline.

Use of intravenous is limited to hospital settings. While subcutaneous injection of the medication in a medical facility is also advised, at-home administration of the medication is an option if long-term therapy is required.

If a woman is made to administer her own injections, she should attempt to administer the injection herself after the first few are administered by a skilled nurse. This will assist you in determining the appropriate way to carry out the manipulation and what the typical feelings should be.

There are some nuances you should be aware of when using Clexane on your own.

• Syringes with solution are already ready for use and remove air bubbles from them is not required. If the dosage in one syringe is low, then getting rid of the bubbles can lead to the loss of a certain percentage of the active substance, which is highly undesirable.
• Before the manipulation, it is necessary to clean the skin. A woman should not only wash her hands with soap and water, but also wash the part of the skin where the injection will be performed, and then dry it.
• During the procedure, it is advisable to lie down, but it is permissible to give the injection in a sitting position. It is important to relax and make sure that the woman can clearly see the part of the skin where the injection will be performed.
• The traditional area for administering the drug is the abdomen. The injection is made into the anterolateral or posterolateral surface in turn: on one day the drug is administered on the right, on the second – on the left, and so on. The injection site of "Clexane" should be at least 5 cm from the navel. If there are bruises or "bumps" from previous injections on the skin surface, they should also be at least 5 cm away.
• Before the procedure, you need to wipe the injection site with a cotton swab with alcohol. The fold of skin on the abdomen should be grabbed with two fingers and held until the end of the procedure. The needle is inserted vertically so that it enters the skin fold not from the side, but at a right angle. In addition, it is important to insert the needle completely along its entire length.
• The medication is injected by pressing the finger on the plunger along its entire length until the entire solution gets under the skin. At this time, a protective mechanism is triggered, due to which the needle automatically closes. Only after this is the fold released.
• To remove the needle, you need to pull it vertically back so that the syringe does not deviate to the side. At the end of the manipulation, you need to apply cotton wool with alcohol to the injection site, but you should not massage the injection site, otherwise bruises may form.

Every patient is given a different dosage of "Clexane" based on their condition and the likelihood that they will form blood clots. A specific expectant mother’s drug regimen is also established separately for her.

The medication must usually be injected once daily; however, on occasion, the daily dosage must be administered in two injections.

Medication is stopped gradually to prevent blood loss, and dose increases can only be made with a doctor’s approval. Only in cases where internal bleeding is discovered or there is a chance of an early birth can you abruptly stop injecting Clexane.

Reviews

Reviews regarding the use of Clexane during pregnancy are largely positive. It is confirmed that the medication can prevent thrombosis, and it is deemed effective. Many women report that these injections enable them to safely carry a child to term even when the coagulogram changes in a dangerous way. The requirement to inject into the abdomen (which can be uncomfortable at times), the drug’s high cost, and the frequent occurrence of bruises and seals are listed as drawbacks. Doctors claim that "Clexane" helps to maintain pregnancy under strict guidelines and is safe for the developing foetus.

Clexane" can be very helpful in treating some pregnancy-related health problems, particularly in women who have diseases that raise their risk of blood clots. It’s crucial to use it only under a doctor’s close supervision, though.

Even though "Clexane" has many advantages, there are risks involved, so you should always carefully follow your doctor’s instructions. Pay attention to the prescribed dosage and make sure you show up for all scheduled check-ups so your doctor can assess how well the medication is working for you.

Do not hesitate to contact your doctor if you have any questions or if you experience any side effects while taking "Clexane." The most important things are your health and the safety of your unborn child, and your doctor is there to help you every step of the way.

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