Use of Dioxidine in the treatment of children, is it worth instilling it into the nose?

Parents frequently have to make tough decisions when it comes to treating their children, particularly when it comes to prescription drugs that aren’t often given to young patients. One such drug that raises doubts is dioxidine, a potent antibacterial agent. Although it was not officially approved for treating nasal issues in children, it has garnered attention as a potential treatment for serious infections in adults.

Many physicians recommend Dioxidine for children’s nasal use, saying that it helps get rid of chronic infections when other therapies don’t work. Some experts, however, caution about the possible risks and contend that the potential negative effects are not worth it, particularly given the developing body of a child.

As a parent, it is imperative that you consider the advantages and disadvantages of any treatment involving dioxidine and speak with medical professionals. This article will discuss if it’s okay to apply this medication to a child’s nose and what to think about before deciding.

Release form

"Dioxidine" is presently offered in a number of formats:

• A solution that can be used externally or injected. It is produced in two concentrations. A drug with a lower concentration (0.5%) can also be injected into a vein. "Dioxidine" in this form is ampoules with a greenish-yellowish transparent odorless solution. One ampoule contains 5 or 10 ml of medicine, and one package includes 5-10 ampoules.
• 5% ointment, which is used only locally. Such a drug is produced in tubes and jars that contain from 30 to 100 g of a greenish-yellow substance.

Composition

The drug’s primary ingredient is known as hydroxymethylquinoxaline dioxide. In a 0.5% solution, there are 5 mg per milliliter, and in a 1% solution, there are 10 mg per milliliter. Sterile water is the only auxiliary material used in this form. The active ingredient in 100 g of ointment is 5 g, and monoglycerides, nipagin, macrogol, and nipazole are added as supplements.

Principle of action

The medication is a bactericidal antimicrobial that works against a variety of microorganisms, including proteus, klebsiella, shigella, staphylococci, and clostridia. The medication stops these bacteria’s cells from synthesizing DNA, which disrupts the structure of membranes and nucleotide formation and ultimately kills the microbes. Because it promotes the creation of active oxygen forms, the medication is particularly useful in anaerobic environments.

Indications

"Dioxidine" is particularly needed in hospitals for infectious purulent diseases. Injections of 0.5% solution administered intravenously are typically prescribed for life-threatening conditions such as sepsis and purulent meningitis. However, because of the high risk of overdose and potential harm to the adrenal glands, injections of the drug are not administered to children. Numerous potent antimicrobial medications have been approved for use in children, including premature babies and infants.

Surgeons, urologists, and dentists prescribe the medication for local use. The medication is used to treat purulent pleurisy, peritonitis, purulent cystitis, pneumonia with abscesses, and gallbladder suppuration. "Dioxidine" is used to cleanse burns that are infected and to treat advanced trophic skin lesions and deep wounds. For pustular skin infections, the medication is also prescribed for external treatment (compresses, lotsions).

ENT physicians frequently recommend "Dioxidine" for the nose, and ophthalmologists may do the same if bacteria have harmed the conjunctiva. This kind of medication is gargled for sore throats and dripped into the ears for purulent otitis.

The medication is being dripped into the nasal passages due to a persistently runny nose that is not improving with other forms of treatment, such as antibiotics from different groups. Simultaneously, the medication can be applied to the nose in cases where the disease is bacterial and the discharge has a disagreeable odor and a greenish hue.

Some mothers continue to give their kids nose injections of dioxin. The view that follows explains why and how this is done.

Complex drops containing "Dioxidine," vasoconstrictors, hormones, and other medications (e.g., "Dexamethasone," "Xylen," "Nazivin," and "Hydrocortisone") are frequently prescribed. For these drops, a unique recipe is chosen for every patient. They are used not only for frontal sinusitis, prolonged sinusitis, adenoiditis, and sinusitis.

Nebulizer inhalations with "Dioxidine" may be prescribed for cases of purulent bronchitis, pneumonia, or lung abscess. In this manner, the medication directly targets the pathogens in the infected tissues. The medication needs to be diluted with saline for these kinds of procedures.

From what age is it allowed to take

Age under 18 is one of the contraindications listed in the annotation for "Dioxidine." Children can also use the medication, but only under a doctor’s prescription, who will also establish the necessary dosage and confirm that there are indications for the treatment. Dripping "Dioxidine" into a child’s nose without first visiting a pediatrician is forbidden.

Contraindications

In the following situations, the medication shouldn’t be used:

• If the child has an individual intolerance.
• If the function of the adrenal glands of the small patient is impaired.

If renal function is compromised, the medication must be used under medical supervision.

Side effects

Since the medication affects both human and DKN bacterial cells, it is regarded as toxic; however, if the doctor’s recommended dosage is followed, no adverse effects are seen when using the medication locally. In addition, treating the skin’s or mucous membrane’s "dioxidine" may result in an allergic reaction that manifests as dermatitis or itching.

A sensitivity sample should be used to begin treatment in order to prevent this kind of side effect. A tiny patch of skin is treated with the medication. If the drug is to be administered by nose, one drop should be inserted into each nostril. If there are no unfavorable symptoms after three to six hours, the medication is taken at the doctor’s recommended dosage.

Instructions for use and dosage

Vienna Injections Only when there are strong indications and under a doctor’s supervision is 0.5% of dioxidine made. These medications are typically used when cephalosporins, carbapenems, or other effective antibiotics are ineffective or intolerable. The drug is only administered intravenously by drip, and a syringe, drainage tube, or catheter is used to inject the drug into the bronchi or cavities. Each case of "Dioxidine" has a different dosage and method of use.

Tampons soaked in the solution are used as part of the "Dioxidine" treatment for burns or purulent wounds. They are applied and changed on a regular basis to cleaned wound surfaces. For this kind of treatment, 0.5% and 1% solutions can be used, but occasionally a more diluted liquid preparation is needed. It is diluted to a concentration of 0.1-0.2% using saline or water for injection.

It is important to clear any pathological discharge from the nasal cavity or ear canal before applying 0.5% "Dioxidine" drops to the ear or nose. Another option is to rinse with salt water or a solution made with seawater. The drug is then given in the dosage that the physician has recommended.

Typically, 1-3 times a day, 2-3 drops of a 0.5% solution are injected into the nose. Treatment should be discontinued right away if any concerning symptoms (such as dizziness or itching) manifest. The medication is typically used for three to five days. Dripping such a remedy for more than seven days is not advised.

When using "Dioxidine" for cough inhalations, saline should be diluted with 0.5% of the medication in a 1 to 2 ratio and 1% solution in a 1 to 4 ratio. Take 3–4 milliliters of diluted medication for a single procedure. Using a nebulizer, the child should gently inhale the medication for five to ten minutes.

Overdose

An excessive amount of "Dioxidine" can harm the adrenal glands, resulting in dystrophic alterations in the organ’s cortex. Controlling the solution’s concentration and the dosage that is recommended for children is crucial because of this.

Dioxidine is occasionally injected into the nose of children for treatment, but it’s vital to think about whether this is actually safe and beneficial. Although it has some potential benefits, its use in children should be carefully considered because of possible side effects and the availability of safer alternatives. Prior to administering Dioxidine for nasal treatment in children, parents should confer with healthcare professionals to assess the advantages and disadvantages.

Interaction with other drugs

Numerous other medications, such as antihistamines, antibiotics, hormonal anti-inflammatory drugs, and others, are compatible with "dioxidine." In this situation, the physician should determine if the medications can be taken at the same time while taking the diagnosis and other information into consideration.

Terms of sale

Since each drug’s usage has unique qualities and restrictions, you can only purchase "Dioxidine" in a pharmacy with a doctor’s prescription. The cost of ten ampoules of the medication is approximately 340–400 rubles, and a tube containing thirty grams of ointment is approximately 320–350 rubles.

Storage features

• The shelf life of the drug in liquid form is 2 years, and the ointment – 3 years.
• The optimal storage temperature for liquid "Dioxidine" is from 15 to 25 degrees Celsius.
• The ointment should be stored at a temperature below +20 degrees.
• If the temperature during storage drops below +15, crystals may appear in the solution. Such a drug should be heated in a water bath so that all the sediment dissolves again, and the drug itself becomes transparent.
• An opened ampoule of "Dioxidine" should be used immediately. If the medicine is used in the nose, then a new ampoule is opened for each instillation. This can be avoided by pouring the medicine from an open ampoule into a bottle of nasal drops or drawing it into a syringe, and then measuring out the required amount for one procedure.

Reviews

Reviews regarding the use of "Dioxidine" in children vary. Mothers attest to the medication’s good efficacy in treating purulent infections in many of them and commend it for being widely accessible and reasonably priced. Parents have reported in other reviews that this remedy appears to cause allergies or that there is no therapeutic effect.

Mothers who fear the toxic effects of "Dioxidine" and would never risk using it on their child have also expressed negative opinions. Many pediatricians (including Dr. Komarovsky) agree with them, preferring to prescribe antibiotics for infants that are safe to use in childhood and are currently made available by a variety of pharmaceutical companies.

Topic	Details
What is Dioxidine?	Dioxidine is an antibacterial medication often used for infections. However, its use in children is controversial.
Is it safe for children?	Doctors do not commonly recommend Dioxidine for children due to its potential side effects. It is usually considered too strong for young kids.
When is it prescribed?	In rare cases, Dioxidine may be prescribed if other treatments do not work, but this should only be done under strict medical supervision.
Should it be instilled into the nose?	Many specialists advise against using Dioxidine in the nose for children. Safer alternatives are usually available for nasal infections.
What are the risks?	Side effects of Dioxidine can include allergic reactions, toxicity, and damage to tissues, making it risky for children.

It’s crucial to consider the advantages and disadvantages of using dioxin for pediatric nasal problems. Dioxidine is a potent antimicrobial agent, but because of potential side effects and a lack of long-term research, its use in pediatric patients is frequently contested.

A medical expert should be consulted by parents before beginning any new treatment. A physician can offer tailored guidance depending on the particular condition and general health of a child. To guarantee the safest and most efficient course of treatment, it is imperative to abide by medical advice.

Ultimately, even though dioxin may have some advantages, particularly in extreme circumstances, it’s important to use it carefully and under a doctor’s supervision. To guarantee your child receives the best care possible, make educated decisions.

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